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Cyclotides Insert into Lipid Bilayers to Form Membrane Pores and Destabilize the Membrane through Hydrophobic and Phosphoethanolamine-specific Interactions

Cyclotides are a family of plant-derived circular proteins with potential therapeutic applications arising from their remarkable stability, broad sequence diversity, and range of bioactivities. Their membrane-binding activity is believed to be a critical component of their mechanism of action. Using...

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Main Authors: Wang, Conan K., Wacklin, Hanna P., Craik, David J.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527971/
https://ncbi.nlm.nih.gov/pubmed/23129773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.421198
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