Alcohol-induced One-carbon Metabolism Impairment Promotes Dysfunction of DNA Base Excision Repair in Adult Brain

The brain is one of the major targets of chronic alcohol abuse. Yet the fundamental mechanisms underlying alcohol-mediated brain damage remain unclear. The products of alcohol metabolism cause DNA damage, which in conditions of DNA repair dysfunction leads to genomic instability and neural death. We...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Fowler, Anna-Kate, Hewetson, Aveline, Agrawal, Rajiv G., Dagda, Marisela, Dagda, Raul, Moaddel, Ruin, Balbo, Silvia, Sanghvi, Mitesh, Chen, Yukun, Hogue, Ryan J., Bergeson, Susan E., Henderson, George I., Kruman, Inna I.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2012
विषय:
DNA and Chromosomes
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527940/
https://ncbi.nlm.nih.gov/pubmed/23118224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.401497
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