Alcohol-induced One-carbon Metabolism Impairment Promotes Dysfunction of DNA Base Excision Repair in Adult Brain

The brain is one of the major targets of chronic alcohol abuse. Yet the fundamental mechanisms underlying alcohol-mediated brain damage remain unclear. The products of alcohol metabolism cause DNA damage, which in conditions of DNA repair dysfunction leads to genomic instability and neural death. We...

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Bibliographische Detailangaben
Hauptverfasser: Fowler, Anna-Kate, Hewetson, Aveline, Agrawal, Rajiv G., Dagda, Marisela, Dagda, Raul, Moaddel, Ruin, Balbo, Silvia, Sanghvi, Mitesh, Chen, Yukun, Hogue, Ryan J., Bergeson, Susan E., Henderson, George I., Kruman, Inna I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
DNA and Chromosomes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527940/
https://ncbi.nlm.nih.gov/pubmed/23118224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.401497
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