Na(+)/H(+) Exchanger Regulatory Factor 1 (NHERF1) Directly Regulates Osteogenesis

Bone formation requires synthesis, secretion, and mineralization of matrix. Deficiencies in these processes produce bone defects. The absence of the PDZ domain protein Na(+)/H(+) exchange regulatory factor 1 (NHERF1) in mice, or its mutation in humans, causes osteomalacia believed to reflect renal p...

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Bibliographische Detailangaben
Hauptverfasser: Liu, Li, Alonso, Veronica, Guo, Lida, Tourkova, Irina, Henderson, Sarah E., Almarza, Alejandro J., Friedman, Peter A., Blair, Harry C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527918/
https://ncbi.nlm.nih.gov/pubmed/23109343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.422766
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