Tau Oligomers Impair Artificial Membrane Integrity and Cellular Viability

The microtubule-associated protein Tau is mainly expressed in neurons, where it binds and stabilizes microtubules. In Alzheimer disease and other tauopathies, Tau protein has a reduced affinity toward microtubules. As a consequence, Tau protein detaches from microtubules and eventually aggregates in...

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Main Authors: Flach, Katharina, Hilbrich, Isabel, Schiffmann, Andrea, Gärtner, Ulrich, Krüger, Martin, Leonhardt, Marion, Waschipky, Hanka, Wick, Lukas, Arendt, Thomas, Holzer, Max
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527910/
https://ncbi.nlm.nih.gov/pubmed/23129775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.396176
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