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Mathematical modelling predicts synergistic anti-tumor effects of combining a macrophage-based, hypoxia-targeted, gene therapy with chemotherapy
Tumor hypoxia is associated with low rates of cell proliferation and poor drug delivery, limiting the efficacy of many conventional therapies such as chemotherapy. Since many macrophages accumulate in hypoxic regions of tumors, one way to target tumor cells in these regions could be to use genetical...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3527892/ https://ncbi.nlm.nih.gov/pubmed/21363914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2834 |
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