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Mathematical modelling predicts synergistic anti-tumor effects of combining a macrophage-based, hypoxia-targeted, gene therapy with chemotherapy

Tumor hypoxia is associated with low rates of cell proliferation and poor drug delivery, limiting the efficacy of many conventional therapies such as chemotherapy. Since many macrophages accumulate in hypoxic regions of tumors, one way to target tumor cells in these regions could be to use genetical...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Owen, Markus R, Stamper, I Johanna, Muthana, Munitta, Richardson, Giles W, Dobson, Jon, Lewis, Claire E, Byrne, Helen M
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527892/
https://ncbi.nlm.nih.gov/pubmed/21363914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2834
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