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Pathogenesis of hypertrophic cardiomyopathy caused by myozenin 2 mutations is independent of calcineurin activity

AIMS: The role of calcineurin protein phosphatase 2B (PP2B) in the pathogenesis of human hypertrophic cardiomyopathy (HCM) remains unsettled. We determined potential involvement of calcineurin in the pathogenesis of HCM caused by mutations in myozenin 2 (MYOZ2), an inhibitor of calcineurin. METHODS...

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Detalhes bibliográficos
Main Authors: Ruggiero, Alessandra, Chen, Suet Nee, Lombardi, Raffaella, Rodriguez, Gabriela, Marian, Ali J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527764/
https://ncbi.nlm.nih.gov/pubmed/22987565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvs294
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