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Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms

Alternative splicing is regulated by splicing factors that modulate splice site selection. In some cases, however, splicing factors show antagonistic activities by either activating or repressing splicing. Here, we show that these opposing outcomes are based on their binding location relative to reg...

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Detalhes bibliográficos
Main Authors: Erkelenz, Steffen, Mueller, William F., Evans, Melanie S., Busch, Anke, Schöneweis, Katrin, Hertel, Klemens J., Schaal, Heiner
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527730/
https://ncbi.nlm.nih.gov/pubmed/23175589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.037044.112
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