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The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin—antitoxin complex from M. tuberculosis reveals a Mg(2+) ion in the active site and a putative RNA-binding site
VapBC pairs account for 45 out of 88 identified toxin-antitoxin (TA) pairs in the Mycobacterium tuberculosis (Mtb) H37Rv genome. A working model suggests that under times of stress, antitoxin molecules are degraded, releasing the toxins to slow the metabolism of the cell, which in the case of VapC t...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Wiley Subscription Services, Inc., A Wiley Company
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3527712/ https://ncbi.nlm.nih.gov/pubmed/23011806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2161 |
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