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The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin—antitoxin complex from M. tuberculosis reveals a Mg(2+) ion in the active site and a putative RNA-binding site

VapBC pairs account for 45 out of 88 identified toxin-antitoxin (TA) pairs in the Mycobacterium tuberculosis (Mtb) H37Rv genome. A working model suggests that under times of stress, antitoxin molecules are degraded, releasing the toxins to slow the metabolism of the cell, which in the case of VapC t...

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Dettagli Bibliografici
Autori principali: Min, Andrew B, Miallau, Linda, Sawaya, Michael R, Habel, Jeff, Cascio, Duilio, Eisenberg, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley Subscription Services, Inc., A Wiley Company 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527712/
https://ncbi.nlm.nih.gov/pubmed/23011806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2161
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