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Back to the Future: Can physical models of passive membrane permeability help reduce drug candidate attrition and move us beyond QSPR?
It is widely recognized that ADMET (Adsorption, Distribution, Metabolism, Excretion - Toxicology) liabilities kill the majority of drug candidates that progress to clinical trials. The development of computational models to predict small molecule membrane permeability is therefore of considerable sc...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3527668/ https://ncbi.nlm.nih.gov/pubmed/23066853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12074 |
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