UBE4B Levels Are Correlated with Clinical Outcomes in Neuroblastoma Patients and with Altered Neuroblastoma Cell Proliferation and Sensitivity to EGFR Inhibitors

BACKGROUND: The UBE4B gene, located on chromosome 1p36, encodes a ubiquitin ligase that interacts with Hrs, a protein involved in EGFR trafficking, suggesting a link between EGFR trafficking and neuroblastoma pathogenesis. We have analyzed the roles of UBE4B in the outcomes of neuroblastoma patients...

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Hlavní autoři: Zage, Peter E., Sirisaengtaksin, Natalie, Liu, Yin, Gireud, Monica, Brown, Brandon S., Palla, Shana, Richards, Kristen N., Hughes, Dennis P.M., Bean, Andrew J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527637/
https://ncbi.nlm.nih.gov/pubmed/22990745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.27785
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