Macrophage Metalloelastase (MMP-12) Deficiency Mitigates Retinal Inflammation and Pathological Angiogenesis in Ischemic Retinopathy

Pathological angiogenesis is a major cause of vision loss in ischemic and inflammatory retinal diseases. Recent evidence implicates macrophage metalloelastase (MMP-12), a macrophage-derived elastinolytic protease in inflammation, tissue remodeling and angiogenesis. However, little is known about the...

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Main Authors: Li, Jingming, Wang, Joshua J., Peng, Qisheng, Chen, Chen, Humphrey, Mary Beth, Heinecke, Jay, Zhang, Sarah X.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527600/
https://ncbi.nlm.nih.gov/pubmed/23285156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052699
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