Morphological Characteristics of Motor Neurons Do Not Determine Their Relative Susceptibility to Degeneration in a Mouse Model of Severe Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is a leading genetic cause of infant mortality, resulting primarily from the degeneration and loss of lower motor neurons. Studies using mouse models of SMA have revealed widespread heterogeneity in the susceptibility of individual motor neurons to neurodegeneration, bu...

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Autors principals: Thomson, Sophie R., Nahon, Joya E., Mutsaers, Chantal A., Thomson, Derek, Hamilton, Gillian, Parson, Simon H., Gillingwater, Thomas H.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527597/
https://ncbi.nlm.nih.gov/pubmed/23285108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052605
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