Morphological Characteristics of Motor Neurons Do Not Determine Their Relative Susceptibility to Degeneration in a Mouse Model of Severe Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is a leading genetic cause of infant mortality, resulting primarily from the degeneration and loss of lower motor neurons. Studies using mouse models of SMA have revealed widespread heterogeneity in the susceptibility of individual motor neurons to neurodegeneration, bu...

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Bibliographic Details
Main Authors: Thomson, Sophie R., Nahon, Joya E., Mutsaers, Chantal A., Thomson, Derek, Hamilton, Gillian, Parson, Simon H., Gillingwater, Thomas H.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527597/
https://ncbi.nlm.nih.gov/pubmed/23285108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052605
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