Neutrophil-Derived Myeloperoxidase Aggravates Non-Alcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Deficient Mice

BACKGROUND: Chronic inflammation and oxidative stress play fundamental roles in the pathogenesis of non-alcoholic steatohepatitis (NASH). Previously, we reported that myeloperoxidase (MPO), an aggressive oxidant-generating neutrophil enzyme, is associated with NASH severity in man. We now investigat...

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Main Authors: Rensen, Sander S., Bieghs, Veerle, Xanthoulea, Sofia, Arfianti, Evi, Bakker, Jaap A., Shiri-Sverdlov, Ronit, Hofker, Marten H., Greve, Jan Willem, Buurman, Wim A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527496/
https://ncbi.nlm.nih.gov/pubmed/23285030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052411
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