Reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators

The structure of the Fab region of antibodies is critical to their function. By introducing single cysteine substitutions into various positions of the heavy and light chains of the Fab region of trastuzumab, a potent antagonist of HER2, and using thiol chemistry to link the different Fabs together,...

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Main Authors: Scheer, Justin M., Sandoval, Wendy, Elliott, J. Michael, Shao, Lily, Luis, Elizabeth, Lewin-Koh, Sock-Cheng, Schaefer, Gabriele, Vandlen, Richard
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527469/
https://ncbi.nlm.nih.gov/pubmed/23284778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051817
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