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Dnmt3a Protects Active Chromosome Domains against Cancer-Associated Hypomethylation
Changes in genomic DNA methylation patterns are generally assumed to play an important role in the etiology of human cancers. The Dnmt3a enzyme is required for the establishment of normal methylation patterns, and mutations in Dnmt3a have been described in leukemias. Deletion of Dnmt3a in a K-ras–de...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Public Library of Science
2012
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3527206/ https://ncbi.nlm.nih.gov/pubmed/23284304 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003146 |
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