The NAD(+)-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

Circadian rhythms govern a large array of metabolic and physiological functions. The central clock protein CLOCK has HAT properties. It directs acetylation of histone H3 and of its dimerization partner BMAL1 at Lys537, an event essential for circadian function. We show that the HDAC activity of the...

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Autores principales: Nakahata, Yasukazu, Kaluzova, Milota, Grimaldi, Benedetto, Sahar, Saurabh, Hirayama, Jun, Chen, Danica, Guarente, Leonard P., Sassone-Corsi, Paolo
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526943/
https://ncbi.nlm.nih.gov/pubmed/18662547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.07.002
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