Dihydrofolate Reductase from Neisseria sp

Members of the genus Neisseria are relatively nonsusceptible to trimethoprim, an inhibitor of dihydrofolate reductase. For example, the minimal inhibitory concentration (MIC) of trimethoprim for N. gonorrhoeae ranges from 2 to 70 μg/ml, whereas the MIC for Escherichia coli is 0.2 μg/ml or less. In a...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Averett, Devron R., Roth, Barbara, Burchall, James J., Baccanari, David P.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1979
Subjects:
Physiological Effects and Microbial Susceptibility
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352677/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/111611/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.15.3.428
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