Vpu Downmodulates Two Distinct Targets, Tetherin and Gibbon Ape Leukemia Virus Envelope, through Shared Features in the Vpu Cytoplasmic Tail

During human immunodeficiency virus-1 (HIV-1) assembly, the host proteins CD4 (the HIV-1 receptor) and tetherin (an interferon stimulated anti-viral protein) both reduce viral fitness. The HIV-1 accessory gene Vpu counteracts both of these proteins, but it is thought to do so through two distinct me...

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Main Authors: Lucas, Tiffany M., Janaka, Sanath K., Stephens, Edward B., Johnson, Marc C.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2012
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526647/
https://ncbi.nlm.nih.gov/pubmed/23284757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051741
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