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Vpu Downmodulates Two Distinct Targets, Tetherin and Gibbon Ape Leukemia Virus Envelope, through Shared Features in the Vpu Cytoplasmic Tail
During human immunodeficiency virus-1 (HIV-1) assembly, the host proteins CD4 (the HIV-1 receptor) and tetherin (an interferon stimulated anti-viral protein) both reduce viral fitness. The HIV-1 accessory gene Vpu counteracts both of these proteins, but it is thought to do so through two distinct me...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3526647/ https://ncbi.nlm.nih.gov/pubmed/23284757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051741 |
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