Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5

BACKGROUND: Cerebral blood flow (CBF) is known to be dysregulated in persons with human immunodeficiency virus 1 (HIV-1), for uncertain reasons. This is an important issue because impaired vasoreactivity has been associated with increased risk of ischemic stroke, elevated overall cardiovascular risk...

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Bibliographische Detailangaben
Hauptverfasser: Silva, Jharon, Polesskaya, Oksana, Knight, Walter, Zheng, Johnny Ting, Granger, Megan, Lopez, Tenée, Ontiveros, Fernando, Feng, Changyong, Yan, Chen, Kasischke, Karl A, Dewhurst, Stephen
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526511/
https://ncbi.nlm.nih.gov/pubmed/23167821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-253
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