A novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) splice variant with an alternative exon 1 potentially encoding an extended N-terminus

BACKGROUND: The major rate-limiting enzyme for de novo cholesterol synthesis is 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR). HMGCR is sterically inhibited by statins, the most commonly prescribed drugs for the prevention of cardiovascular events. Alternative splicing of HMGCR has been im...

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Bibliographic Details
Main Authors: Stormo, Camilla, Kringen, Marianne K, Grimholt, Runa M, Berg, Jens P, Piehler, Armin P
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526503/
https://ncbi.nlm.nih.gov/pubmed/22989091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-13-29
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