Autoantibodies against 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase (HMGCR) in Patients with Statin-Associated Autoimmune Myopathy

OBJECTIVE: In addition to inducing a self-limited myopathy, statin use is associated with an immune-mediated necrotizing (IMNM) myopathy with autoantibodies recognizing ~ 200 and ~100 kDa autoantigens. Identifying these molecules will clarify disease mechanism and facilitate diagnosis. METHODS: The...

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Autori principali: Mammen, Andrew L., Chung, Tae, Christopher-Stine, Lisa, Rosen, Paul, Rosen, Antony, Casciola-Rosen, Livia A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335400/
https://ncbi.nlm.nih.gov/pubmed/21360500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.30156
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