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Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele

KitL, via its receptor cKit, supports primordial germ cell (PGC) growth, survival, migration and reprogramming to pluripotent embryonic germ cells (EGCs). However, the signaling downstream of KitL and its regulation in PGCs remain unclear. A constitutively activating mutation, cKit(V558Δ), causes ga...

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Bibliografske podrobnosti
Main Authors: Chen, Li, Faire, Mehlika, Kissner, Michael D., Laird, Diana J.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526162/
https://ncbi.nlm.nih.gov/pubmed/23077213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds430
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