Loss of ACE2 Exaggerates High-Calorie Diet–Induced Insulin Resistance by Reduction of GLUT4 in Mice

ACE type 2 (ACE2) functions as a negative regulator of the renin-angiotensin system by cleaving angiotensin II (AII) into angiotensin 1–7 (A1–7). This study assessed the role of endogenous ACE2 in maintaining insulin sensitivity. Twelve-week-old male ACE2 knockout (ACE2KO) mice had normal insulin se...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Takeda, Masao, Yamamoto, Koichi, Takemura, Yukihiro, Takeshita, Hikari, Hongyo, Kazuhiro, Kawai, Tatsuo, Hanasaki-Yamamoto, Hiroko, Oguro, Ryosuke, Takami, Yoichi, Tatara, Yuji, Takeya, Yasushi, Sugimoto, Ken, Kamide, Kei, Ohishi, Mitsuru, Rakugi, Hiromi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2013
Témata:
Pathophysiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526031/
https://ncbi.nlm.nih.gov/pubmed/22933108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0177
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky