Loss of ACE2 Exaggerates High-Calorie Diet–Induced Insulin Resistance by Reduction of GLUT4 in Mice

ACE type 2 (ACE2) functions as a negative regulator of the renin-angiotensin system by cleaving angiotensin II (AII) into angiotensin 1–7 (A1–7). This study assessed the role of endogenous ACE2 in maintaining insulin sensitivity. Twelve-week-old male ACE2 knockout (ACE2KO) mice had normal insulin se...

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Detalhes bibliográficos
Main Authors: Takeda, Masao, Yamamoto, Koichi, Takemura, Yukihiro, Takeshita, Hikari, Hongyo, Kazuhiro, Kawai, Tatsuo, Hanasaki-Yamamoto, Hiroko, Oguro, Ryosuke, Takami, Yoichi, Tatara, Yuji, Takeya, Yasushi, Sugimoto, Ken, Kamide, Kei, Ohishi, Mitsuru, Rakugi, Hiromi
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
Assuntos:
Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526031/
https://ncbi.nlm.nih.gov/pubmed/22933108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0177
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