Low Trimethoprim Susceptibility of Anaerobic Bacteria Due to Insensitive Dihydrofolate Reductases

All the 28 Bacteroides fragilis strains investigated were susceptible to sulfamethoxazole (minimal inhibitory concentration < 16 μg/ml) and resistant to trimethoprim (TMP; minimal inhibitory concentration > 4 μg/ml). Synergism between sulfamethoxazole and TMP was present in all strains at a ratio of...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Then, Rudolf L., Angehrn, Peter
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1979
Assuntos:	Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352591/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/218496/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.15.1.1
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