Low Trimethoprim Susceptibility of Anaerobic Bacteria Due to Insensitive Dihydrofolate Reductases

All the 28 Bacteroides fragilis strains investigated were susceptible to sulfamethoxazole (minimal inhibitory concentration < 16 μg/ml) and resistant to trimethoprim (TMP; minimal inhibitory concentration > 4 μg/ml). Synergism between sulfamethoxazole and TMP was present in all strains at a ra...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Then, Rudolf L., Angehrn, Peter
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1979
Subjects:
Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352591/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/218496/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.15.1.1
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