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Promoter Methylation Analysis of IDH Genes in Human Gliomas
Mutations in isocitrate dehydrogenase (IDH)-1 or -2 are found in the majority of WHO grade II and III astrocytomas and oligodendrogliomas, and secondary glioblastomas. Almost all described mutations are heterozygous missense mutations affecting a conserved arginine residue in the substrate binding s...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3525876/ https://ncbi.nlm.nih.gov/pubmed/23267435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2012.00193 |
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