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The Effect of DNA CpG Methylation on the Dynamic Conformation of a Nucleosome
DNA methylation is an important epigenetic mark that is known to induce chromatin condensation and gene silencing. We used a time-domain fluorescence lifetime measurement to quantify the effects of DNA hypermethylation on the conformation and dynamics of a nucleosome. Nucleosomes reconstituted on an...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Biophysical Society
2012
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3525854/ https://ncbi.nlm.nih.gov/pubmed/23260052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.11.012 |
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