Limitations of Time-Resolved Fluorescence Suggested by Molecular Simulations: Assessing the Dynamics of T cell Receptor Binding Loops

Time-resolved fluorescence anisotropy (TRFA) has a rich history in evaluating protein dynamics. Yet as often employed, TRFA assumes that the motional properties of a covalently tethered fluorescent probe accurately portray the motional properties of the protein backbone at the probe attachment site....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Scott, Daniel R., Vardeman, Charles F., Corcelli, Steven A., Baker, Brian M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2012
Schlagworte:
Proteins and Nucleic Acids
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525847/
https://ncbi.nlm.nih.gov/pubmed/23260055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.10.037
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