Macrophage-tropic HIV-1 variants from brain demonstrate alterations in the way gp120 engages both CD4 and CCR5

BR-derived HIV-1 strains have an exceptional ability to enter macrophages via mechanisms involving their gp120 Env that remain incompletely understood. Here, we used cell-based affinity-profiling methods and mathematical modeling to generate quantitative VERSA metrics that simultaneously measure Env...

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Autors principals: Salimi, Hamid, Roche, Michael, Webb, Nicholas, Gray, Lachlan R., Chikere, Kelechi, Sterjovski, Jasminka, Ellett, Anne, Wesselingh, Steve L., Ramsland, Paul A., Lee, Benhur, Churchill, Melissa J., Gorry, Paul R.
Format: Artigo
Idioma:Inglês
Publicat: Society for Leukocyte Biology 2013
Matèries:
Receptors, Signal Transduction, & Genes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525831/
https://ncbi.nlm.nih.gov/pubmed/23077246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0612308
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