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Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: Effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment

Cisplatin, a platinum-derived chemotherapeutic agent, produces mechanical and cold allodynia reminiscent of chemotherapy-induced neuropathy in humans. The endocannabinoid system represents a novel target for analgesic drug development. The endocannabinoid consists of endocannabinoids (e.g. anandamid...

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Bibliografiske detaljer
Main Authors: Guindon, Josée, Lai, Yvonne, Takacs, Sara M., Bradshaw, Heather B., Hohmann, Andrea G.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525790/
https://ncbi.nlm.nih.gov/pubmed/23127915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2012.10.013
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