Evidence for Conversion of 5-Fluorocytosine to 5-Fluorouracil in Humans: Possible Factor in 5-Fluorocytosine Clinical Toxicity

A gas chromatographic-mass spectrometric method for detecting 5-fluorouracil (5-FU) in serum at concentrations as low as 10 ng/ml was used to determine to what extent 5-FU was present in the serum of patients taking oral 5-fluorocytosine (5-FC). Preliminary studies in two patients and two healthy vo...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Diasio, Robert B., Lakings, Duane E., Bennett, John E.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1978
Soggetti:	Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352577/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/742878/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.14.6.903
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