Alpha-Tocopheryl Succinate Inhibits Autophagic Survival of Prostate Cancer Cells Induced by Vitamin K3 and Ascorbate to Trigger Cell Death

BACKGROUND: The redox-silent vitamin E analog α-tocopheryl succinate (α-TOS) was found to synergistically cooperate with vitamin K3 (VK3) plus ascorbic acid (AA) in the induction of cancer cell-selective apoptosis via a caspase-independent pathway. Here we investigated the molecular mechanism(s) und...

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Main Authors: Tomasetti, Marco, Nocchi, Linda, Neuzil, Jiri, Goodwin, Jacob, Nguyen, Maria, Dong, Lanfeng, Manzella, Nicola, Staffolani, Sara, Milanese, Claudio, Garrone, Beatrice, Alleva, Renata, Borghi, Battista, Santarelli, Lory, Guerrieri, Roberto
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525640/
https://ncbi.nlm.nih.gov/pubmed/23272231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052263
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