Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans-Infection Through Recognition of Viral Membrane Gangliosides

Dendritic cells (DCs) are essential antigen-presenting cells for the induction of immunity against pathogens. However, HIV-1 spread is strongly enhanced in clusters of DCs and CD4(+) T cells. Uninfected DCs capture HIV-1 and mediate viral transfer to bystander CD4(+) T cells through a process termed...

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Autors principals: Izquierdo-Useros, Nuria, Lorizate, Maier, Puertas, Maria C., Rodriguez-Plata, Maria T., Zangger, Nadine, Erikson, Elina, Pino, Maria, Erkizia, Itziar, Glass, Bärbel, Clotet, Bonaventura, Keppler, Oliver T., Telenti, Amalio, Kräusslich, Hans-Georg, Martinez-Picado, Javier
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525531/
https://ncbi.nlm.nih.gov/pubmed/23271952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001448
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