Ocular Surface Extracellular DNA and Nuclease Activity Imbalance: A New Paradigm for Inflammation in Dry Eye Disease

PURPOSE. We determined whether nucleases are deficient in the tear fluid of dry eye disease (DED) patients, and whether this causes extracellular DNA (eDNA) and neutrophil extracellular trap (NET) accumulation in the precorneal tear film, thus causing ocular surface inflammation. METHODS. Exfoliated...

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Detalhes bibliográficos
Main Authors: Sonawane, Snehal, Khanolkar, Vishakha, Namavari, Abed, Chaudhary, Shweta, Gandhi, Sonal, Tibrewal, Sapna, Jassim, Sarmad H., Shaheen, Brittany, Hallak, Joelle, Horner, John H., Newcomb, Martin, Sarkar, Joy, Jain, Sandeep
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525138/
https://ncbi.nlm.nih.gov/pubmed/23169882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.12-10430
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