Ocular Surface Extracellular DNA and Nuclease Activity Imbalance: A New Paradigm for Inflammation in Dry Eye Disease

PURPOSE. We determined whether nucleases are deficient in the tear fluid of dry eye disease (DED) patients, and whether this causes extracellular DNA (eDNA) and neutrophil extracellular trap (NET) accumulation in the precorneal tear film, thus causing ocular surface inflammation. METHODS. Exfoliated...

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Hauptverfasser: Sonawane, Snehal, Khanolkar, Vishakha, Namavari, Abed, Chaudhary, Shweta, Gandhi, Sonal, Tibrewal, Sapna, Jassim, Sarmad H., Shaheen, Brittany, Hallak, Joelle, Horner, John H., Newcomb, Martin, Sarkar, Joy, Jain, Sandeep
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Association for Research in Vision and Ophthalmology 2012
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525138/
https://ncbi.nlm.nih.gov/pubmed/23169882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.12-10430
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