Single nucleotide polymorphism genotyping by two colour melting curve analysis using the MGB Eclipse™ Probe System in challenging sequence environment

Probe and primer design for single nucleotide polymorphism (SNP) detection can be very challenging for A-T DNA-rich targets, requiring long sequences with lower specificity and stability, while G-C-rich DNA targets present limited design options to lower GC-content sequences only. We have developed...

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Detalhes bibliográficos
Main Authors: Belousov, Yevgeniy S, Welch, Robert A, Sanders, Silvia, Mills, Alan, Kulchenko, Alena, Dempcy, Robert, Afonina, Irina A, Walburger, David K, Glaser, Cynthia L, Yadavalli, Sunita, Vermeulen, Nicolaas MJ, Mahoney, Walt
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2004
Assuntos:
Primary Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525082/
https://ncbi.nlm.nih.gov/pubmed/15588480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-7364-1-3-209
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