Noncanonical control of C. elegans germline apoptosis by the insulin/IGF-1 and Ras/MAPK signaling pathways

The insulin/IGF-1 pathway controls a number of physiological processes in the nematode worm Caenorhabditis elegans, including development, aging and stress response. We previously found that the Akt/PKB ortholog AKT-1 dampens the apoptotic response to genotoxic stress in the germline by negatively r...

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Hlavní autoři: Perrin, A J, Gunda, M, Yu, B, Yen, K, Ito, S, Forster, S, Tissenbaum, H A, Derry, W B
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3524627/
https://ncbi.nlm.nih.gov/pubmed/22935616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.101
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