Effects of Hypoxemia upon Aminoglycoside Serum Pharmacokinetics in Animals

Hypoxemia causes significant alterations in aminoglycoside serum pharmacokinetics in adult rats and newborn rabbits. The aminoglycoside serum clearances were diminished in hypoxemic animals. Comparisons of intravenous and intramuscular administration imply a delay in uptake of drug from intramuscula...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Mirhij, Najwa J., Roberts, Robert J., Myers, Martin G.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1978
Soggetti:	Pharmacology and Therapeutics
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352462/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/708011/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.14.3.344
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