Pharmacokinetics of Cefaclor in Patients with End Stage Renal Disease and During Hemodialysis

A single 1.0-g dose of cefaclor administered to patients with stable end stage renal disease whose creatinine clearances were <5 ml/min produced a mean peak serum concentration of 48.3 ± 19.8 μg/ml. The half-life was 2.3 ± 0.3 h. Hemodialysis shortened the half-life of a similar dose to 1.6 ± 0.3 h....

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Berman, S. J., Boughton, W. H., Sugihara, J. G., Wong, E. G. C., Sato, M. M., Siemsen, A. W.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1978
Soggetti:	Pharmacology and Therapeutics
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352452/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/708006/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.14.3.281
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