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Combination Therapy With Glucagon And A Novel Plasminogen Activator Inhibitor-1 Derived Peptide Enhances Protection Against Impaired Cerebrovasodilation During Hypotension After Traumatic Brain Injury Through Inhibition of ERK And JNK MAPK
OBJECTIVE: The outcome of traumatic brain injury (TBI) is impaired by hypotension and glutamate, and TBI associated release of endogenous tissue plasminogen activator (tPA) impairs cerebral autoregulation. Glucagon decreases CNS glutamate, lessens neuronal cell injury and improves neurological score...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3524516/ https://ncbi.nlm.nih.gov/pubmed/22642975 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1179/1743132812Y.0000000039 |
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