Ascitic Fluid Cephalosporin Concentrations: Influence of Protein Binding and Serum Pharmacokinetics

Mongrel dogs with ascites created by inferior vena cava ligation were given cephalothin, cephaloridine, cefazolin, and cefamandole to evaluate the effect of protein binding and serum pharmacokinetics on the distribution of cephalosporins into ascitic fluid. Antibiotics were given intramuscularly (15...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Gerding, Dale N., Peterson, Lance R., Legler, Dwight C., Hall, Wendell H., Schierl, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1978
Assuntos:
Pharmacology and Therapeutics
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352439/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/697350/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.14.2.234
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