Carbenoxolone Treatment Ameliorated Metabolic Syndrome in WNIN/Ob Obese Rats, but Induced Severe Fat Loss and Glucose Intolerance in Lean Rats

BACKGROUND: 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) regulates local glucocorticoid action in tissues by catalysing conversion of inactive glucocorticoids to active glucocorticoids. 11β-HSD1 inhibition ameliorates obesity and associated co-morbidities. Here, we tested the effect of 11β-...

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Main Authors: Prasad Sakamuri, Siva Sankara Vara, Sukapaka, Mahesh, Prathipati, Vijay Kumar, Nemani, Harishankar, Putcha, Uday Kumar, Pothana, Shailaja, Koppala, Swarupa Rani, Ponday, Lakshmi Raj Kumar, Acharya, Vani, Veetill, Giridharan Nappan, Ayyalasomayajula, Vajreswari
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3524236/
https://ncbi.nlm.nih.gov/pubmed/23284633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050216
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