Carbenoxolone Treatment Ameliorated Metabolic Syndrome in WNIN/Ob Obese Rats, but Induced Severe Fat Loss and Glucose Intolerance in Lean Rats

BACKGROUND: 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) regulates local glucocorticoid action in tissues by catalysing conversion of inactive glucocorticoids to active glucocorticoids. 11β-HSD1 inhibition ameliorates obesity and associated co-morbidities. Here, we tested the effect of 11β-...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Prasad Sakamuri, Siva Sankara Vara, Sukapaka, Mahesh, Prathipati, Vijay Kumar, Nemani, Harishankar, Putcha, Uday Kumar, Pothana, Shailaja, Koppala, Swarupa Rani, Ponday, Lakshmi Raj Kumar, Acharya, Vani, Veetill, Giridharan Nappan, Ayyalasomayajula, Vajreswari
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2012
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3524236/
https://ncbi.nlm.nih.gov/pubmed/23284633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050216
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