Putting the brakes on p53-driven apoptosis

Following genotoxic stress, cells activate a complex, kinase-based signaling network to arrest the cell cycle and initiate DNA repair or apoptosis. The tumor suppressor p53 lies at the heart of this DNA damage response. p53 mediates the transactivation of both cell cycle-regulating and pro-apoptotic...

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Bibliographic Details
Main Authors: Höpker, Katja, Hagmann, Henning, Khurshid, Safiya, Chen, Shuhua, Schermer, Bernhard, Benzing, Thomas, Reinhardt, Hans Christian
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3524207/
https://ncbi.nlm.nih.gov/pubmed/22983126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.21997
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