The Anorectic Effect of GLP-1 in Rats Is Nutrient Dependent

GLP-1-induced insulin secretion from the β-cell is dependent upon glucose availability. The purpose of the current study was to determine whether CNS GLP-1 signaling is also glucose-dependent. We found that fasting blunted the ability of 3(rd) cerebroventricularly (i3vt)-administered GLP-1 to reduce...

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Détails bibliographiques
Auteurs principaux: Sandoval, Darleen, Barrera, Jason G., Stefater, Margaret A., Sisley, Stephanie, Woods, Stephen C., D’Alessio, David D., Seeley, Randy J.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3524167/
https://ncbi.nlm.nih.gov/pubmed/23284795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051870
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