Epigenetic Changes in Basal Cell Carcinoma Affect SHH and WNT Signaling Components

BACKGROUND: The genetic background of Basal Cell Carcinoma (BCC) has been studied extensively, while its epigenetic makeup has received comparatively little attention. Epigenetic alterations such as promoter hypermethylation silence tumor suppressor genes (TSG) in several malignancies. OBJECTIVE: We...

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Main Authors: Brinkhuizen, Tjinta, van den Hurk, Karin, Winnepenninckx, Véronique J. L., de Hoon, Joep P., van Marion, Ariënne M., Veeck, Jürgen, van Engeland, Manon, van Steensel, Maurice A. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3524166/
https://ncbi.nlm.nih.gov/pubmed/23284750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051710
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